The US Coast Guard says that a debris field located in the North Atlantic suggests that a submersible missing since Sunday, with five passengers on board, suffered a "catastrophic implosion".
The vessel, which had limited oxygen supplies, went missing deep under the ocean on Sunday after setting off to explore the wreck of the Titanic.
It prompted a massive five-day search and rescue operation led by US, Canadian and French agencies.
The agency offered its condolences to the families of the victims and said it could not confirm if their bodies would ever be recovered.
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