The Gaza Health Ministry says at least 500 people have been killed in an airstrike on a hospital compound in the centre of Gaza City.
Israeli officials deny targeting the hospital and say they believe the blast was caused by a rocket from Hamas or Islamic Jihad that fell short and struck the site.
News of the deadly incident came hours before President Biden departed for Israel for a visit to deliver a message of support following the Hamas attacks there.
President Biden was also planning to meet the leaders of Egypt, Jordan and the Palestinian Authority but that meeting has been canceled following the Gaza hospital attack.
Clive Myrie presents BBC News at Ten reporting by Sarah Smith in Washington and Jeremy Bowen in Israel.
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