At least 90 Palestinians have been killed in an Israeli air strike on a designated humanitarian area, according to the Hamas-run health ministry in Gaza.
They said about 300 people have been injured, in an attack which Israel says targeted senior Hamas leader Mohammed Deif and his deputy Rafa Salama.
In a news conference Israeli Prime Minister Benjamin Netanyahu said there was "no certainty" that either of them had been killed.
The strike hit the al-Mawasi area near Khan Younis, which the Israeli military has designated as a humanitarian zone.
Mr Netanyahu said he gave the order for the operation to go ahead after being briefed by his general security forces.
An Israeli military official claimed tha the strike took place in an "open area" where there were "no civilians".
Ben Brown presents BBC News reporting by Fergal Keane and Lucy Williamson.
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